Lease term expiration date
Lease Expiration Date
Vesting period of stock option
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Segment Information
Segment Reporting, Policy [Policy Text Block]
Net operating loss carryforwards
Operating Loss Carryforwards
Operating Loss Carryforwards, Total
Forecast [Member]
Amount to be paid for consulting services
Amount To Be Paid For Consulting Services
The annual amount of compensation to be paid over the term of a consulting agreement.
Auditor Location
Operating expenses:
Operating Expenses [Abstract]
Loss from operations
Operating Income (Loss)
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
Milestone payments
Milestone Payment Amount
Amount of payment due upon reaching milestone.
Lease term commencement date
Lease Term Commencement Date
Lease term commencement date.
Other Commitments [Table]
Other Commitments [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company
Income Tax Disclosure [Abstract]
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Shares available for grant
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Marketable Debt Securities
Marketable Securities, Policy [Policy Text Block]
Purchase of property and equipment
Payments to Acquire Property, Plant, and Equipment
Payments to Acquire Property, Plant, and Equipment, Total
Massachusetts [Member]
MOROCCO
Geographical
Geographical [Axis]
Common stock, $0.001 par value per share; 115,000,000 shares authorized as of December 31, 2021 and December 31, 2020; 17,710,450 and 15,367,730 shares issued and outstanding as of December 31, 2021 and December 31, 2020, respectively
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Entity Address, State or Province
Entity Address, State or Province
Employees and Directors [Member]
Employees and Directors [Member]
Employees and directors.
Series A and Series B member
Series A And Series B [Member]
Series A and Series B [Member]
Right-of-use assets
Increase Decrease In Right Of Use Assets
The increase (decrease) in the right-of-use assets during the reporting period.
Total liabilities
Liabilities
Unrealized gain (loss) on marketable debt securities
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total
Schedule of Domestic and Foreign Components of Loss Before Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Private Offering [Member]
Private Offering [Member]
Private offering of securities, as part of a merger agreement.
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Reverse stock split of common stock
Stockholders' Equity, Reverse Stock Split
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Laboratory Equipment [Member]
Laboratory Equipment [Member]
Laboratory equipment.
Remaining Restricted Common Units [Member]
Remaining Restricted Common Units [Member]
Remaining Restricted Common Units.
Business Combinations [Abstract]
Prepaid research and development expenses
Prepaid Research And Development Expenses
Amount of asset related to consideration paid in advance for costs related to research and development.
Fixed assets, useful life
Property, Plant and Equipment, Estimated Useful Lives
Business Acquisition [Line Items]
Business Acquisition [Line Items]
General and Administrative [Member]
General and Administrative Expense [Member]
Weighted average remaining contractual term, Exercisable as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Restricted cash
Restricted Cash
Restricted Cash, Total
Fair Value
Marketable debt securities
Debt Securities, Available-for-sale, Current
Debt Securities, Available-for-sale, Current, Total
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Schedule Of Related Party Transactions By Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
City Area Code
City Area Code
Assumptions used to Determine Fair Value of Stock Options Granted
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Total deferred tax assets
Deferred Tax Assets, Gross
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Commitments and contingencies (See Note 9)
Commitments and Contingencies
Issuance of Common Stock. Net, shares
Issuance of common stock
Stock Issued During Period, Shares, New Issues
Area of office space
Area Of Office Space
Area of office space.
Scenario [Axis]
Consolidated Entities
Consolidated Entities [Domain]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Related Party
Related Party [Domain]
Real Estate [Domain]
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Income Statement [Abstract]
First Anniversary [Member]
First Anniversary [Member]
First anniversary.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Prepaid Expenses and Other Current Assets
Prepaid Expenses And Other Current Assets [Text Block]
The entire disclosure for prepaid expenses and other current assets.
Net cash provided by investing activities
Net Cash Provided by (Used in) Investing Activities
Property and equipment included in accounts payable and accrued expenses
Capital Expenditures Incurred but Not yet Paid
Accrued payroll and related expenses
Employee-related Liabilities, Current
Employee-related Liabilities, Current, Total
General and administrative
General and Administrative Expense
General and Administrative Expense, Total
Fixed assets, net
Property and equipment, net
Property, Plant and Equipment, Net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Common stock, shares issued
Common stock, shares issued
Common Stock, Shares, Issued
Common Stock, Shares, Issued, Total
New Consulting Agreement [Member]
New Consulting Agreement [Member]
New Consulting Agreement Member
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Deferred Tax Liabilities, Gross, Total
Total deferred tax liabilities
Amortized Cost
Debt Securities, Available-for-sale, Amortized Cost
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Summary of significant accounting policies.
Interim Period, Costs Not Allocable
Interim Period, Costs Not Allocable [Domain]
Option Indexed to Issuer's Equity, Type
Option Indexed to Issuer's Equity, Type [Domain]
Security Exchange Name
Security Exchange Name
Comprehensive income (loss):
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Statistical Measurement
Statistical Measurement [Domain]
Furniture and Fixtures [Member]
Furniture and Fixtures [Member]
Cash and cash equivalents
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Summary of Purchase Price Paid in Merger
Summary Of Estimated Purchase Price Paid In Merger Table [Text Block]
Tabular disclosure of the preliminary estimate of the purchase price paid as part of a merger. May include, but is not limited to, information for shares issued (number, fair value per share, total fair value) and transaction costs.
Subsequent Event Type
Subsequent Event Type [Domain]
Warrants price per share
Warrants Issued Price Per Share
Per unit amount of prefunded warrant issued.
Document Period End Date
Document Period End Date
Legal Entity Type of Counterparty
Legal Entity Type of Counterparty [Domain]
Other current and noncurrent assets
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Other Current And Noncurrent Assets
Amount of other assets expected to be realized or consumed both before one year or the normal operating cycle, if longer, and after one year or the normal operating cycle, if longer, acquired at the acquisition date.
Restricted cash
Restricted Cash, Noncurrent
Income Statement Location
Income Statement Location [Axis]
Investments
Investments [Domain]
Total accrued expenses
Accrued expenses
Accrued Liabilities, Current
Massachusetts [Member]
MASSACHUSETTS
Number of shares of the combined organization owned by Zafgen stockholders
Stockholders' Equity Note, Changes in Capital Structure, Subsequent Changes to Number of Common Shares
Related Party Transaction
Related Party Transaction [Axis]
Accounting Standards Update 2018-13 [Member]
Common stock, shares authorized
Common Stock, Shares Authorized
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Equity Interest Issued or Issuable, Type
Equity Interest Issued or Issuable, Type [Domain]
Agreement expiration date
Agreement Expiration Date
Agreement Expiration Date.
Operating lease liabilities, current
Operating Lease, Liability, Current
Related Party
Related Party [Axis]
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Real Estate, Type of Property [Axis]
Annual base rent
Sublease annual base rent.
Total potentially dilutive shares
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Vesting
Vesting [Axis]
Stock Based Compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Entity Address, Address Line Two
Entity Address, Address Line Two
Current Fiscal Year End Date
Current Fiscal Year End Date
Shares issued to private placement, Shares
Shares Issued To Private Placement
The amount of shares issued during the period as part of a private placement.
Net increase in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Purchased of equipment
Related Party Transaction, Purchases from Related Party
Right-of-use asset
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Right Of Use Asset
Amount of lessee's right to use underlying asset under operating lease, acquired at the acquisition date.
Other Temporary Differences
Deferred Tax Assets, Other
Period of agreement
Period Of Agreement
Period of agreement.
Capital stock ownership percentage
Equity Method Investment, Ownership Percentage
Assets
Assets [Abstract]
2016 Equity and Incentive Plan [Member]
Two Thousand Sixteen Equity And Incentive Plan [Member]
Two thousand sixteen equity and incentive plan.
Sales agreement, description
Sales Agreement Description
Description of sales agreement..
Reverse Stock Split
Reverse Stock Split Policy [Text Block]
Disclosure of accounting policy for a reverse stock split.
Description of Business and Organization
Business Description and Basis of Presentation [Text Block]
Property and equipment, net
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment, Total
2022
Lessee, Operating Lease, Liability, to be Paid, Year One
Accounts payable
Accounts Payable, Current
Accounts Payable, Current, Total
Private Placement [Member]
Private Placement [Member]
Common stock, par value
Common stock, par value per share
Common Stock, Par or Stated Value Per Share
Net capitalized R&D deferred tax assets
Capitalized R&D Expenses
Deferred Tax Assets, in Process Research and Development
Federal and state research and development tax credit
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
State and Local Jurisdiction [Member]
State and Local Jurisdiction [Member]
Weighted average common shares outstanding, basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Beginning balance, shares
Ending balance, shares
Shares, Outstanding
Additional paid-in capital
Additional Paid in Capital, Common Stock
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
No Expiration [Member]
No Expiration [Member]
No expiration.
Stockholders' Equity Note [Abstract]
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Increase in fair value
Increase (Decrease) in Fair Value of Price Risk Fair Value Hedging Instruments
Earliest Tax Year [Member]
Earliest Tax Year [Member]
Loss before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Document Type
Document Type
Vesting
Vesting [Domain]
2020 Equity Incentive Plan [Member]
2020 Equity Incentive Plan [Member]
Two Thousand Twenty Equity Incentive Plan [Member]
Two thousand twenty equity incentive plan.
Domestic Tax Authority [Member]
Domestic Tax Authority [Member]
Share Based Compensation Arrangement By Share Based Payment Award Threshold Number Of Shares Allowed To Issue
The minimum threshold number of shares used to determine the maximum number of shares that may be issued under the Plan.
Minimum level of maximum number of shares allowed to be issued
Fair value of consideration issued in effect of the Merger
Business Combination, Consideration Transferred
Business Combination, Consideration Transferred, Total
Preferred stock; $0.001 par value per share; 5,000,000 shares authorized as of December 31, 2021 and December 31, 2020; no shares issued and outstanding as of December 31, 2021 and December 31, 2020
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Operating lease liabilities
Operating Lease, Liability, Noncurrent
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Total current assets
Assets, Current
Accounting Standards Update 2016-13 [Member]
Stock-Based Compensation
Share-based Payment Arrangement [Policy Text Block]
MTS Health Partners [Member]
M T S Health Partners [Member]
MTS Health Partners.
Accrued research and development expenses
Accrued Research And Development Expense Current
Carrying value as of the balance sheet date of obligations incurred through that date and payable for expenses related to research and development. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Options to Purchase Common Stock [Member]
Share-based Payment Arrangement, Option [Member]
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Weighted average remaining contractual term, outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Share-based compensation arrangement by share-based payment award, description
Share-based Compensation Arrangement by Share-based Payment Award, Terms of Award
Income tax benefit
Income Tax Expense (Benefit)
Income Tax Expense (Benefit), Total
Supplemental disclosure of non-cash investing and financing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Leases [Abstract]
Antidilutive Securities
Antidilutive Securities [Axis]
Milestone payments due
Milestone Liability
Amount of payment due for milestones that have been achieved
2014 Stock Option and Incentive Plan [Member]
Two Thousand Fourteen Stock Option And Incentive Plan [Member]
Two thousand fourteen stock option and incentive plan.
2014 Stock Option and Incentive Plan [Member]
Security Deposit Liability
Lease security deposits letters of credit
Prepaid insurance
Prepaid Insurance
Aggregate intrinsic value, Vested and expected to vest as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Net operating Loss Carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Common stock outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Plan Name
Plan Name [Axis]
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Total operating expenses
Operating Expenses
Dividend paid
Dividends Payable
Deferred tax assets:
Deferred Tax Assets, Gross [Abstract]
Gross Unrealized Losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Weighted average exercise price, balance
Weighted average exercise price, balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Weighted average exercise price prior to conversion
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Prior To Conversion
The weighted average exercise price of outstanding and unexercised options to purchase common units available immediately prior to a merger.
Schedule of Maturities of Lease Liabilities Due Under Lease Agreements
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Warrants exercise price
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrant exercise price
Net loss per share, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Gross Unrealized Gains
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
2023
Lessee, Operating Lease, Liability, to be Paid, Year Two
Net loss
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Reconciliation of Federal Statutory Income Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Accrued Expenses
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Concentrations of Credit Risk and Significant Suppliers
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Restricted common units granted
Partners Capital Account Restricted Common Units Granted
The number of restricted common units granted.
Weighted average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Research and Development [Member]
Research and Development Expense [Member]
Document Fiscal Period Focus
Document Fiscal Period Focus
Accounting Policies [Abstract]
Accumulated other comprehensive gain
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Entity Address, Address Line One
Entity Address, Address Line One
Number of shares, Outstanding
Number of shares, Outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
License agreement consideration deduction percentage
License Agreement Consideration Deduction Percentage
The amount that may be deducted from consideration due to Licensor 2 as a percentage of consideration paid to Licensor 1, whereby Licensor 1 is the identified party.
Total current liabilities
Liabilities, Current
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Commercial Paper [Member]
Commercial Paper [Member]
Commercial paper (due within 1 year) [Member]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Title of Individual
Title of Individual [Axis]
Aggregate intrinsic value, outstanding
Aggregate intrinsic value, outstanding
Aggregate intrinsic value, outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Total lease payments
Lessee, Operating Lease, Liability, to be Paid
Increase in shares reserved for future issuance
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized
Lab Equipment [Member]
Equipment [Member]
Net cash used in operating activities:
Net Cash Provided by (Used in) Operating Activities
Capital contributions from related party
Capital contributions from related party
Proceeds from Contributed Capital
Multiplied by the fair value per share of Zafgen common stock
Business Acquisition, Share Price
Percentage of compensation for services equal to gross proceeds
Percentage Of Compensation For Services Equal To Gross Proceeds
The fee for services as a percentage of gross proceeds resulting from the sale of shares of common stock under a sales agreement.
Cash, cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Equity Components
Equity Components [Axis]
Sixth sublease year member
Sixth Sublease Year [Member]
Sixth Sublease Year
Tax Period
Tax Period [Axis]
Current assets:
Assets, Current [Abstract]
Entity Registrant Name
Entity Registrant Name
Other comprehensive loss:
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Pennsylvania [Member]
PENNSYLVANIA
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Stockholders' Equity and Stock Options
Stockholders' Equity Note Disclosure [Text Block]
Entity Interactive Data Current
Entity Interactive Data Current
Entity Address, City or Town
Entity Address, City or Town
Operating loss carryforwards, description
Operating Loss Carryforwards, Limitations on Use
Equity Interest Type
Equity Interest Type [Axis]
Expected term (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Vests Over Forty Eight Months [Member]
Vests Over Forty Eight Months [Member]
Vests over forty eight months.
Trading Symbol
Trading Symbol
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Gain on disposal of fixed asset
Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property
Issuance of common stock to placement agent for advisory fees in lieu of cash and other issuances of common stock, Shares
Issuance Of Common Stock To Placement Agent For Advisory Fees In Lieu Of Cash And Other Issuances Of Common Stock
The amount of shares issued to a placement agent for advisory fees in lieu of cash and other issuances of common stock.
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Less: imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Patent Costs
Intangible Assets, Finite-Lived, Policy [Policy Text Block]
Zafgen [Member]
Zafgen [Member]
Zafgen.
Foreign Tax Authority [Member]
Foreign Tax Authority [Member]
Local Phone Number
Local Phone Number
Chondrial [Member]
Chondrial [Member]
Chondrial.
Vested Recognized Immediately [Member]
Vested Recognized Immediately [Member]
Vested recognized immediately.
Total stockholders' equity
Balances
Balances
Stockholders' Equity Attributable to Parent
Subsequent Event Type
Subsequent Event Type [Axis]
Unrecognized tax benefits
Unrecognized Tax Benefits
Unrecognized Tax Benefits, Beginning Balance
Unrecognized Tax Benefits, Ending Balance
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Undesignated preferred stock, shares issued
Preferred stock, shares issued
Preferred Stock, Shares Issued
Preferred Stock, Shares Issued, Total
Total cash equivalents and marketable debt securities
Cash equivalents and marketable debt securities
Assets, Fair Value Disclosure
Statistical Measurement
Statistical Measurement [Axis]
Entity Small Business
Entity Small Business
Purchase of marketable debt securities
Payments to Acquire Debt Securities, Available-for-sale
Weighted average exercise price post conversion
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Post Conversion
The weighted average exercise price of outstanding and unexercised options to purchase common units available immediately after a merger.
Undesignated preferred stock, shares outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Tax credit carryforwards
Deferred Tax Assets, Tax Credit Carryforwards
Deferred Tax Assets, Tax Credit Carryforwards, Total
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Federal and State [Member]
Domestic And State Local Jurisdiction [Member]
Domestic and state local jurisdiction.
Number of shares, Forfeited/Expired
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Total
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Short-term Debt, Type [Domain]
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Schedule of Net Deferred Tax Assets
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Merger Agreement [Member]
Merger Agreement [Member]
The number of common stock shares issued in exchange for one share of the other company's common stock as part of a merger agreement.
Common stock voting rights
Common Stock, Voting Rights
Estimated useful life
Property, Plant and Equipment, Useful Life
Business Acquisition
Business Acquisition [Axis]
Operating loss carryforwards, minimum percentage of taxable income in tax period
Operating Loss Carryforwards Minimum Percentage Of Taxable Income In Tax Period
The amount of limitation on operating loss carryforwards as a percentage of taxable income in any one tax period.
Summary of Marketable Debt Securities
Schedule of Available-for-sale Securities Reconciliation [Table Text Block]
First Sublease Year [Member]
First Sublease Year [Member]
First sublease year member.
Weighted average exercise price, Granted
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Merger transaction costs
Payments Of Merger Transaction Costs
The cash outflow associated with merger transaction costs.
Lease liability, net of current portion
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Capital Lease Obligation Noncurrent
Amount of lease liabilities due after one year or the normal operating cycle, if longer, assumed at the acquisition date.
Sale of Stock
Sale of Stock [Domain]
Increases acquired as a result of the Merger with Zafgen
Valuation Allowance Deferred Tax Asset Change In Amount Merger
Amount of increase (decrease) in the valuation allowance due to merger.
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Plan Name
Plan Name [Domain]
Total other comprehensive income (loss)
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Total other comprehensive income
Income Tax Authority
Income Tax Authority [Axis]
Depreciation expense
Depreciation
Depreciation, Total
Net operating loss carryforwards, change in ownership, annual utilization limit
Net Operating Loss Carryforwards And Tax Credit Carryforwards Change In Ownership Annual Utilization Limit
Net operating loss carryforwards and tax credit carryforwards, annual utilization limit due to change in ownership.
Operating lease term
Lessee, Operating Lease, Term of Contract
Increases recorded to income tax provision
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Annual royalty pay obligation
Minimum Annual Royalty Obligation
The minimum annual royalty payment that is required under a contractual arrangement.
Issuance of Common Stock. Net
Stock Issued During Period, Value, New Issues
WFUHS [Member]
Wake Forest University Health Sciences [Member]
Wake Forest University Health Sciences (WFUHS) [Member]
Percentage of outstanding shares
Share Based Compensation Arrangement By Share Based Payment Award Additional Shares Percentage Of Outstanding Stock
The maximum number of shares that may be added annually to the threshold number of shares issued under the Plan, as a percentage of the shares issued and outstanding on the last day of the immediately preceding fiscal year.
Open tax year
Open Tax Year
Cash, cash equivalents, and restricted cash acquired in connection with the Merger
Cash Acquired from Acquisition
Amount of lease liabilities due after one year or the normal operating cycle, if longer, assumed at the acquisition date.
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Lease Obligation Noncurrent
Lease liability, net of current portion
Merger with Zafgen
Business Combinations Policy [Policy Text Block]
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense
Share-based Payment Arrangement, Noncash Expense, Total
Total prepaid expenses and other current assets
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Nonvested Recognize Over Remaining Term [Member]
Nonvested Recognize Over Remaining Term [Member]
Nonvested recognize over remaining term.
Summary of Stock Option Activity
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Related Party Transactions [Abstract]
Schedule of Prepaid Expenses and Other Current Assets
Schedule Of Prepaid Expenses And Other Current Assets Table [Text Block]
Tabular disclosure of the carrying amounts of prepaid expenses and other current assets.
Exchange rate of shares issued per share
Exchange Rate Of Shares Issued Per Share
The number of common stock shares issued in exchange for one share of the other company's common stock as part of a merger agreement.
Number of options to purchase common unit post conversion
Number Of Options To Purchase Common Unit Post Conversion
The number of outstanding and unexercised options to purchase common units available immediately after a merger.
Marketable debt securities acquired
Noncash or Part Noncash Acquisition, Investments Acquired
Net capitalized R&D deferred tax assets realization description
Net Capitalized R D Deferred Tax Assets Realization Description
Description of the limitation that a capitalized research and development deferred tax asset may be subject to.
Number of shares, Exercisable as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Commitments and Contingencies Disclosure [Abstract]
Leased assets obtained in exchange for new operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Total assets
Assets
Significant Other Observable Inputs (Level 2) [Member]
Fair Value, Inputs, Level 2 [Member]
Holdings [Member]
Holdings [Member]
Holdings member.
Other prepaid expenses and other assets
Other Prepaid Expense And Other Current Assets
Amount of asset related to consideration paid in advance for costs that provide economic benefits in future periods, and amount of other assets that are expected to be realized or consumed within one year or the normal operating cycle, if longer, not separately disclosed.
Statement [Line Items]
Statement [Line Items]
Total liabilities and stockholders' equity
Liabilities and Equity
Statement of Cash Flows [Abstract]
Extented period of agreement
Extended Period Of Agreement
Represents extended term of agreement.
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Title of 12(b) Security
Title of 12(b) Security
Total comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Significant Unobservable Inputs (Level 3) [Member]
Fair Value, Inputs, Level 3 [Member]
Number of options to purchase common unit prior to conversion
Number Of Options To Purchase Common Unit Prior To Conversion
The number of outstanding and unexercised options to purchase common units available immediately prior to a merger.
ATM Offering Program [Member]
At The Market Equity Offering Program [Member]
At-the-market equity offering program.
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Award Type [Domain]
Award vesting
Stock option vesting percentage
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Schedule of Fixed Assets, Net
Property, Plant and Equipment [Table Text Block]
Quoted Prices in Active Markets, (Level 1) [Member]
Fair Value, Inputs, Level 1 [Member]
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
2025
Lessee, Operating Lease, Liability, to be Paid, Year Four
Net deferred tax assets / (liabilities)
Deferred Tax Assets, Net
Depreciation expense
Depreciation Expense Excluding Leased Assets
The amount of depreciation expenses recognized in the period, excluding depreciation for leased assets as part of a sublease agreement.
Change in deferred tax asset valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Other income (expense), net
Nonoperating Income (Expense)
Nonoperating Income (Expense), Total
Weighted average exercise price, Vested and expected to vest as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Number of shares, Granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Options to purchase shares of common stock granted
Entity Current Reporting Status
Entity Current Reporting Status
Marketable debt securities
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Marketable Securities
Investment Type
Investment Type [Axis]
Summary of Cash Equivalents and Marketable Debt Securities
Fair Value, Assets Measured on Recurring and Nonrecurring Basis [Table Text Block]
Private Placement, net of transaction costs
Private Placement Net Of Transaction Costs
The value of stock issued during the period as part of a private placement, net of transaction costs.
Entity Voluntary Filers
Entity Voluntary Filers
Scenario [Domain]
Money Market Funds [Member]
Money Market Funds [Member]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Debt Securities Available For Sale [Table]
Debt Securities, Available-for-sale [Table]
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
Summary of Stock-Based Compensation Expense
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Gross sales proceeds under sales agreement remaining amount
The remaining gross sales proceeds available under a sales agreement to sell shares of the Company's common stock.
Gross Sales Proceeds Under Sales Agreement Remaining Amount
Computer Equipment [Member]
Computer Equipment [Member]
Accumulated Other Comprehensive Loss [Member]
AOCI Attributable to Parent [Member]
Auditor Firm ID
Incentive Stock Options [Member]
Incentive Stock Options [Member]
Incentive stock options member.
Series A Preferred Unit Purchase Agreement [Member]
Series A Preferred Unit Purchase Agreement [Member]
Series a preferred unit purchase agreement.
Consulting Agreement [Member]
Consulting Agreement [Member]
Consulting Agreement.
Income Statement Location
Income Statement Location [Domain]
Current liabilities
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Total
Auditor Name
Net loss per share, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Undesignated preferred stock, shares authorized
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Weighted average exercise price, Exercisable as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Accrued expenses
Increase (Decrease) in Accrued Liabilities
Increase (Decrease) in Accrued Liabilities, Total
Minimum [Member]
Minimum [Member]
Weighted average remaining contractual term, Vested and expected to vest as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
2014 Equity Incentive Plan [Member]
Two thousand fourteen equity incentive plan.
Summary of Changes in Valuation Allowance for Deferred Tax Assets
Summary of Valuation Allowance [Table Text Block]
Issuance of warrants
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrant issued
Schedule Of Business Acquisitions By Acquisition [Table]
Schedule of Business Acquisitions, by Acquisition [Table]
Document Annual Report
Document Annual Report
Less: Valuation allowance
Valuation allowance as of the beginning of the year
Valuation Allowance at end of Year
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Valuation Allowance, Total
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Unrecognized compensation expense
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Domestic
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Entity Filer Category
Entity Filer Category
Income Taxes
Income Tax, Policy [Policy Text Block]
Second Series B Bridge Unit Purchase Agreement [Member]
Second Series B Bridge Unit Purchase Agreement [Member]
Second series b bridge unit purchase agreement.
Percentage of likelihood to be realized upon ultimate settlement, description
Likelihood Percentage Minimum
The minimum likelihood percentage threshold used to determine the amount of tax benefit to be recognized.
Document Fiscal Year Focus
Document Fiscal Year Focus
Number of shares, Vested and expected to vest as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Income Taxes
Income Tax Disclosure [Text Block]
Common Units [Member]
Common units.
Going Concern
Going Concern Policy [Text Block]
Disclosure of accounting policy for the assessment of the ability to continue as a going concern.
Fair Value Disclosures [Abstract]
Fixed Assets
Property, Plant and Equipment Disclosure [Text Block]
Maximum [Member]
Maximum [Member]
Entity Central Index Key
Entity Central Index Key
Maturities and sales of marketable debt securities
Proceeds from Sale and Maturity of Debt Securities, Available-for-sale
Proceeds from Sale and Maturity of Debt Securities, Available-for-sale, Total
Employees [Member]
Employees [Member]
Employees.
Business Acquisition, Acquiree
Business Acquisition, Acquiree [Domain]
Payables and Accruals [Abstract]
Lease expenses
Operating Lease, Expense
Prepaid Expense and Other Assets [Abstract]
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Summary of Allocation of Purchase Price to Net Tangible and Intangible Assets Acquired
Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]
Entity Tax Identification Number
Entity Tax Identification Number
Equity Component
Equity Component [Domain]
Undesignated preferred stock, par value
Preferred stock, par value per share
Preferred Stock, Par or Stated Value Per Share
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Gross proceeds
Proceeds from Issuance of Private Placement
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
From Prior Plans [Member]
From Prior Plans [Member]
From Prior Plans [Member]
Series B Bridge Unit Purchase Agreement [Member]
Series B Bridge Unit Purchase Agreement [Member]
Series b bridge unit purchase agreement.
Income Tax Authority
Income Tax Authority [Domain]
Office [Member]
Office [Member]
Office.
Unrecognized compensation expense recognized period
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
U.S Government securities (due within 1 year) [Member]
US Government Corporations and Agencies Securities [Member]
U.S Government Securities [Member]
Deferred tax liabilities:
Deferred Tax Liabilities, Gross [Abstract]
Consolidated Entities
Consolidated Entities [Axis]
Aggregate grant fair value
Share Based Compensation Arrangement By Share Based Payment Award Aggregate Grant Date Fair Value1
The aggregate grant-date fair value of stock options or units.
Option Indexed to Issuer's Equity, Type
Option Indexed to Issuer's Equity, Type [Axis]
Term of plan
Share Based Compensation Arrangement By Share Based Payment Award Duration
The term of the plan.
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Leasehold Improvements [Member]
Maximum number of shares that may be issued under stock option incentive plan
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Minimum level of maximum number of shares allowed to be issued
Statement [Table]
Statement [Table]
Weighted average remaining lease term in years
Operating Lease, Weighted Average Remaining Lease Term
Office and Lab.
Office And Lab [Member]
Office and Lab [Member]
Entity File Number
Entity File Number
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Other assets
Increase (Decrease) in Other Noncurrent Assets
Accumulated Deficit [Member]
Retained Earnings [Member]
Share price per share
Shares Issued, Price Per Share
Accounting Standards Update [Domain]
Accounting Standards Update [Axis]
Accounts payable
Increase (Decrease) in Accounts Payable
Increase (Decrease) in Accounts Payable, Total
Milestone expenses
Milestone Expenses
The amount of expense recognized during the period related to milestones. Such amount may include, but is not limited to, amounts due for attainment of milestones as well as deductions granted as part of a license agreement.
Operating Lease Liability
Deferred Tax Assets Operating Lease Liabilities
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating lease liabilities.
Nature of Expense
Nature of Expense [Axis]
Current liabilities:
Liabilities, Current [Abstract]
IU [Member]
Indiana University Research And Technology Corporation [Member]
Indiana University Research and Technology Corporation.
Subsequent Event [Member]
Subsequent Event [Member]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Present value of lease liabilities
Operating lease liability
Operating Lease, Liability
Operating Lease, Liability, Total
Common Stock [Member]
Common Stock [Member]
Common Stock [Member]
Director [Member]
Director [Member]
Fixed assets, gross
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Accrued professional fees
Accrued Professional Fees, Current
Entity Public Float
Entity Public Float
Purchase price
Purchase price:
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net
Payroll tax receivable
Payroll Taxes Receivable
Carrying amount as of the balance sheet date of payroll taxes previously overpaid to tax authorities (such as U.S. Federal, state and local tax authorities) representing refunds of overpayments or recoveries based on agreed-upon resolutions of disputes.
Cover [Abstract]
Cash, cash equivalents, restricted cash and marketable debt securities acquired merger
Cash Cash Equivalents Restricted Cash And Marketable Debt Securities Acquired Merger
The acquisition of cash, cash equivalents, restricted cash and marketable debt securities that was held by the acquired company, as part of a merger agreement.
Other Commitments [Line Items]
Other Commitments [Line Items]
Related Party Transaction
Related Party Transaction [Domain]
Statement of Stockholders' Equity [Abstract]
Merger with Zafgen Inc., Shares
Stock Issued For Merger Shares
The amount of shares issued during the period as part of a business combination.
Aggregate sale of shares of our common stock
Aggregate Gross Sales Proceeds Under Sales Agreement
The potential aggregate gross sales proceeds available under a sales agreement to sell shares of the Company's common stock.
Aggregate sale of shares of our common stock
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Accrued other
Other Accrued Liabilities, Current
Document Transition Report
Document Transition Report
Weighted average exercise price, Forfeited/Expired
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Letter of Credit [Member]
Short-term Debt, Type [Axis]
Lease extension period
Lessee, Operating Lease, Renewal Term
Final Sublease Year [Member]
Final Sublease Year [Member]
Final sublease year
Research and development expense
Research and development
Research and Development Expense
Research and Development Expense, Total
Weighted average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Fair value of net assets acquired in the Merger, including $1.0 million of marketable debt securities and excluding cash acquired
Fair Value of Assets Acquired
Options to purchase stock
Stock Issued During Period, Shares, Acquisitions
Total stock-based compensation expense
Share-based Payment Arrangement, Expense
Equipment, Furniture and Fixtures and Office Equipment [Member]
Equipment Furniture And Fixtures And Office Equipment [Member]
Equipment, furniture and fixtures and office equipment.
Research and development tax credit carry forwards, beginning of expiration period
Tax Credit Carry Forward Expiration Year Start
The first year in which a tax credit carryforward begins to expire.
Statement of Financial Position [Abstract]
Dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Net operating loss carryforwards, beginning of expiration period
Net Operating Loss Carry Forward Expiration Year Begin
The first year in which a net operating loss carryforward begins to expire.
Lease Contractual Term
Lease Contractual Term [Axis]
2026
Lessee, Operating Lease, Liability, to be Paid, Year Five
Federal statutory income tax rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Gross proceeds from sale of equity
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Gross proceeds from issuance of common stock
Gross Proceeds from Issuance of Common Stock
Gross proceeds from issuance of common stock.
Lease Contractual Term
Lease Contractual Term [Domain]
Chondrial Therapeutics Inc. [Member]
Chondrial Therapeutics Inc [Member]
Chondrial therapeutics inc.
Proceeds from issuance common stock and warrants net offering costs
Proceeds From Issuance Common Stock And Warrants Net Offering Costs
Proceeds from issuance of common stock and prefunded warrants to purchase common stock, net of offering costs.
Net proceeds
Transaction cost
Stock And Warrant Issuance Transaction Costs
Costs incurred during the period related to the issuance of stock and warrants.
Restricted cash
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Restricted Cash
Amount of cash restricted as to withdrawal or usage, acquired at the acquisition date.
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
2024
Lessee, Operating Lease, Liability, to be Paid, Year Three
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Office Sublease
Office Sublease [Member]
Office Sublease [Member]
Shares reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Award Type [Axis]
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to a change in the state tax rate.
Change in state tax rate
Effective Income Tax Rate Reconciliation Change in State Tax Rate
Transaction costs
Business Acquisition, Transaction Costs
Merger with Zafgen Inc.
Stock Issued For Merger Value
The value of stock issued during the period as part of a business combination.
Entity Shell Company
Entity Shell Company
Schedule Of Available For Sale Securities [Line Items]
Debt Securities, Available-for-sale [Line Items]
Liabilities and Stockholders' Equity
Liabilities and Equity [Abstract]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Entity Incorporation State Country Code
Entity Incorporation, State or Country Code
Marketable debt securities
Marketable Securities
Marketable Securities, Total
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary of significant accounting policies.
Amendment Flag
Amendment Flag
Legal Entity of Counterparty, Type
Legal Entity of Counterparty, Type [Axis]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Recently Issued and Adopted Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Title of Individual
Title of Individual [Domain]
Fixed Assets & Intangibles
Deferred Tax Assets Fixed Assets And Intangible Assets
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible fixed assets and intangible assets.
Tax credit carryforward
Tax Credit Carryforward, Amount
Nondeductible permanent differences
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Merger Accounting
Mergers, Acquisitions and Dispositions Disclosures [Text Block]
Operating Right of Use Asset
Deferred Tax Liabilities Operating Lease R Ight Of Use Assets
Amount of deferred tax liability attributable to operating lease right of use assets.
Amortization of premium (discount) on marketable securities
Amortization of Debt Discount (Premium)
Tax Period
Tax Period [Domain]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Other assets
Other Assets, Noncurrent
Other Assets, Noncurrent, Total
Geographical
Geographical [Domain]
Piper Sandler & Co [Member]
Piper Sandler Co [Member]
Piper Sandler & Co.
Corporate Bonds [Member]
Corporate Bond Securities [Member]
Net deferred tax assets before the valuation allowance
Deferred Tax Assets Net Of Liabilities Before Valuation Allowance
Amount, after allocation of deferred tax liability but before allocation of valuation allowances, of deferred tax asset attributable to deductible differences and carryforwards.
Sale of Stock
Sale of Stock [Axis]
Issuance of Common Stock to placement agent for advisory fees in lieu of cash and other issuances of common stock
Issuance Of Common Stock To Placement Agent For Advisory Fees In Lieu Of Cash And Other Issuances Of Common Stock Value
The value of stock issued to a placement agent for advisory fees in lieu of cash and other issuances of common stock.
Fair Value Measurements and Marketable Debt Securities
Fair Value Disclosures [Text Block]
Future Services [Member]
Future Services [Member]
Future Services.
Proceeds from sale of common stock and prefunded warrants, net of issuance costs
Proceeds from Issuance of Common Stock