Entity Central Index Key
Amount of lessee's undiscounted obligation for lease payment for operating lease due after fourth fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Current Reporting Status
Entity Current Reporting Status
Entity Shell Company
Entity Shell Company
Entity File Number
Entity File Number
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity Interactive Data Current
Entity Interactive Data Current
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Entity Incorporation State Country Code
Entity Incorporation State Country Code
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Voluntary Filers
Entity Voluntary Filers
Entity Public Float
Entity Public Float
ICFR Auditor Attestation Flag
Icfr Auditor Attestation Flag
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Statement Of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Marketable debt securities
Available For Sale Securities Debt Securities Current
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Operating lease right-of-use assets
Operating Lease Right Of Use Asset
Restricted cash
Restricted Cash Noncurrent
Other assets
Other Assets Noncurrent
Total assets
Assets
Liabilities and Stockholders’ Equity (Deficit)
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses
Accrued Liabilities Current
Operating lease liabilities, current
Operating Lease Liability Current
Total current liabilities
Liabilities Current
Operating lease liabilities
Operating Lease Liability Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (See Note 9)
Commitments And Contingencies
Stockholders’ equity:
Stockholders Equity [Abstract]
Preferred stock; $0.001 par value per share; 5,000,000 shares authorized as of December 31, 2020 and December 31, 2019; no shares issued and outstanding as of December 31, 2020 and December 31, 2019
Preferred Stock Value
Common stock, $0.001 par value per share; 115,000,000 shares authorized as of December 31, 2020 and December 31, 2019; 15,367,730 and 6,091,250 shares issued and outstanding as of December 31, 2020 and December 31, 2019, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated deficit
Retained Earnings Accumulated Deficit
Accumulated other comprehensive gain
Accumulated Other Comprehensive Income Loss Net Of Tax
Total stockholders’ equity (deficit)
Stockholders Equity
Total liabilities and stockholders’ equity (deficit)
Liabilities And Stockholders Equity
Preferred stock, par value per share
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares issued
Preferred Stock Shares Issued
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value per share
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Income Statement [Abstract]
Operating expenses:
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Other income, net
Nonoperating Income Expense
Net loss
Net Income Loss
Net loss per share, basic and diluted
Earnings Per Share Basic And Diluted
Weighted average common shares outstanding, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Comprehensive loss:
Comprehensive Income Net Of Tax [Abstract]
Net loss
Other comprehensive loss:
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent [Abstract]
Unrealized gain on marketable debt securities
Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent
Total other comprehensive gain
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent
Total comprehensive loss
Comprehensive Income Net Of Tax
The value of stock issued during the period as part of a business combination.
The value of stock issued during the period as part of a private placement, net of transaction costs.
The value of stock issued to a placement agent for advisory fees in lieu of cash and other issuances of common stock.
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Additional Paid In Capital [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Other Comprehensive Income [Member]
Statement [Line Items]
Statement [Line Items]
Balances
Beginning balance, shares
Shares Outstanding
Capital contributions from related party
Proceeds From Contributed Capital
Merger with Zafgen Inc.
Stock Issued For Merger Value
The amount of shares issued during the period as part of a business combination.
Merger with Zafgen Inc., Shares
Stock Issued For Merger Shares
Private Placement, net of transaction costs
Private Placement Net Of Transaction Costs
The amount of shares issued during the period as part of a private placement.
Shares issued to private placement, Shares
Shares Issued To Private Placement
Issuance of Common Stock to placement agent for advisory fees in lieu of cash and other issuances of common stock
Issuance Of Common Stock To Placement Agent For Advisory Fees In Lieu Of Cash And Other Issuances Of Common Stock Value
The amount of shares issued to a placement agent for advisory fees in lieu of cash and other issuances of common stock.
Issuance of common stock to placement agent for advisory fees in lieu of cash and other issuances of common stock, Shares
Issuance Of Common Stock To Placement Agent For Advisory Fees In Lieu Of Cash And Other Issuances Of Common Stock
Stock-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Balances
Ending balance, shares
Offering costs related to MTS issuance
Adjustments To Additional Paid In Capital Stock Issued Ownshare Lending Arrangement Issuance Costs
The increase (decrease) in the right-of-use assets during the reporting period.
The increase (decrease) in operating lease liabilities during the reporting period.
The cash outflow associated with merger transaction costs.
Statement Of Cash Flows [Abstract]
Cash flows from operating activities:
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Stock-based compensation expense
Share Based Compensation
Depreciation expense
Depreciation
Amortization of premium on marketable securities
Investment Income Net Amortization Of Discount And Premium
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Prepaid expenses and other current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued expenses
Increase Decrease In Accrued Liabilities
Right-of-use assets
Increase Decrease In Right Of Use Assets
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Other assets
Increase Decrease In Other Noncurrent Assets
Net cash used in operating activities:
Net Cash Provided By Used In Operating Activities
Cash flows from investing activities:
Net Cash Provided By Used In Investing Activities [Abstract]
Purchase of property and equipment
Payments To Acquire Property Plant And Equipment
Purchase of marketable securities
Payments To Acquire Available For Sale Securities Debt
Maturities and sales of marketable securities
Proceeds From Sale And Maturity Of Available For Sale Securities
Cash, cash equivalents, and restricted cash acquired in connection with the Merger
Cash Acquired From Acquisition
Merger transaction costs
Payments Of Merger Transaction Costs
Net cash provided by (used in) investing activities
Net Cash Provided By Used In Investing Activities
Cash flows from financing activities:
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from sale of common stock and prefunded warrants, net of issuance costs
Proceeds From Issuance Of Common Stock
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Net increase in cash, cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash, cash equivalents and restricted cash at beginning of period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
Cash, cash equivalents and restricted cash at end of period
Supplemental disclosure of non-cash investing and financing activities:
Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]
Fair value of net assets acquired in the Merger, including $1.0 million of marketable debt securities and excluding cash acquired
Fair Value Of Assets Acquired
Property and equipment included in accounts payable and accrued expenses
Capital Expenditures Incurred But Not Yet Paid
Leased assets obtained in exchange for new operating lease liabilities
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Marketable debt securities acquired
Noncash Or Part Noncash Acquisition Investments Acquired1
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Organization, Nature of the Business, COVID-19 Risk and Basis of Presentation
Business Description And Basis Of Presentation [Text Block]
Accounting Policies [Abstract]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Business Combinations [Abstract]
Merger Accounting
Mergers Acquisitions And Dispositions Disclosures [Text Block]
Fair Value Disclosures [Abstract]
Fair Value Measurements and Marketable Debt Securities
Fair Value Disclosures [Text Block]
The entire disclosure for prepaid expenses and other current assets.
Prepaid Expense And Other Assets [Abstract]
Prepaid Expenses and Other Current Assets
Prepaid Expenses And Other Current Assets [Text Block]
Fixed Assets
Property Plant And Equipment Disclosure [Text Block]
Payables And Accruals [Abstract]
Accrued Expenses
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Stockholders Equity Note [Abstract]
Stockholders' Equity and Stock Options
Stockholders Equity Note Disclosure [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments
Commitments And Contingencies Disclosure [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Related Party Transactions [Abstract]
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Merger with Zafgen
Business Combinations Policy
Basis of Presentation
Basis Of Accounting Policy Policy [Text Block]
Disclosure of accounting policy for a reverse stock split.
Reverse Stock Split
Reverse Stock Split Policy [Text Block]
Disclosure of accounting policy for the assessment of the ability to continue as a going concern.
Going Concern Assessment
Going Concern Policy [Text Block]
Use of Estimates
Use Of Estimates
Concentrations of Credit Risk and Significant Suppliers
Concentration Risk Credit Risk
Cash and Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Marketable Debt Securities
Marketable Securities Policy
Property and Equipment
Property Plant And Equipment Policy [Text Block]
Impairment of Long-Lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Segment Information
Segment Reporting Policy Policy [Text Block]
Research and Development Costs
Research And Development Expense Policy
Patent Costs
Intangible Assets Finite Lived Policy
Stock-Based Compensation
Share Based Compensation Option And Incentive Plans Policy
Income Taxes
Income Tax Policy [Text Block]
Disclosure of accounting policy for comprehensive loss.
Comprehensive Loss
Comprehensive Loss Policy [Text Block]
Net Loss Per Share
Earnings Per Share Policy [Text Block]
Recently Issued and Adopted Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Tabular disclosure of the preliminary estimate of the purchase price paid as part of a merger. May include, but is not limited to, information for shares issued (number, fair value per share, total fair value) and transaction costs.
Summary of Purchase Price Paid in Merger
Summary Of Estimated Purchase Price Paid In Merger Table [Text Block]
Summary of Allocation of Purchase Price to Net Tangible and Intangible Assets Acquired
Schedule Of Recognized Identified Assets Acquired And Liabilities Assumed Table [Text Block]
Summary of Cash Equivalents and Marketable Debt Securities
Fair Value Assets Measured On Recurring And Nonrecurring Basis Table [Text Block]
Summary of Marketable Debt Securities
Schedule Of Available For Sale Securities Reconciliation Table [Text Block]
Tabular disclosure of the carrying amounts of prepaid expenses and other current assets.
Schedule of Prepaid Expenses and Other Current Assets
Schedule Of Prepaid Expenses And Other Current Assets Table [Text Block]
Schedule of Fixed Assets, Net
Property Plant And Equipment [Text Block]
Schedule of Accrued Expenses
Schedule Of Accrued Liabilities Table [Text Block]
Assumptions used to Determine Fair Value of Stock Options Granted
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Summary of Stock Option Activity
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Stock-Based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Schedule of Maturities of Lease Liabilities Due Under Lease Agreements
Lessee Operating Lease Liability Maturity Table [Text Block]
Schedule of Domestic and Foreign Components of Loss Before Income Taxes
Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block]
Reconciliation of Federal Statutory Income Tax Rate
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Schedule of Net Deferred Tax Assets
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Summary Changes in the Valuation Allowance for Deferred Tax Assets
Summary Of Valuation Allowance [Text Block]
If determined, state the month and year in which SAD Phase 1 clinical trial resumed & conducting the clinical trial at one clinical trial site.
Consolidated Entities
Consolidated Entities [Axis]
Consolidated Entities
Consolidated Entities [Domain]
Zafgen.
Zafgen [Member]
Zafgen [Member]
Chondrial.
Chondrial [Member]
Chondrial [Member]
Business Acquisition
Business Acquisition [Axis]
Business Acquisition, Acquiree
Business Acquisition Acquiree [Domain]
The number of common stock shares issued in exchange for one share of the other company's common stock as part of a merger agreement.
Merger Agreement [Member]
Merger Agreement [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Private offering of securities, as part of a merger agreement.
Private Offering [Member]
Private Offering [Member]
Phase 1 clinical trial resume period
Phase1 Clinical Trial Resume Period
The number of common stock shares issued in exchange for one share of the other company's common stock as part of a merger agreement.
Reverse stock split of common stock
Stockholders Equity Reverse Stock Split
Exchange rate of shares issued per share
Exchange Rate Of Shares Issued Per Share
Amount of cash, cash equivalents and marketable securities.
Net loss
Cash, cash equivalents and marketable securities
Cash Cash Equivalents Marketable Securities
The acquisition of cash, cash equivalents, restricted cash and marketable debt securities that was held by the acquired company, as part of a merger agreement.
Proceeds from issuance of common stock and prefunded warrants to purchase common stock, net of offering costs.
Cash, cash equivalents, restricted cash and marketable debt securities acquired merger
Cash Cash Equivalents Restricted Cash And Marketable Debt Securities Acquired Merger
Proceeds from issuance common stock and warrants net offering costs
Proceeds From Issuance Common Stock And Warrants Net Offering Costs
Capital contributions from related party
Summary of significant accounting policies.
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Equipment, furniture and fixtures and office equipment.
Equipment, Furniture and Fixtures and Office Equipment [Member]
Equipment Furniture And Fixtures And Office Equipment [Member]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Minimum [Member]
Minimum [Member]
Maximum [Member]
Maximum [Member]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Options to Purchase Common Stock [Member]
Employee Stock Option [Member]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Cash equivalents
Cash Equivalents At Carrying Value
Estimated useful life
Property Plant And Equipment Useful Life
The minimum likelihood percentage threshold used to determine the amount of tax benefit to be recognized.
Percentage of likelihood to be realized upon ultimate settlement, description
Likelihood Percentage Minimum
The number of warrants issued during the period.
The exercise price of each class of warrants or rights outstanding.
Warrant issued
Class Of Warrant Or Right Issued
Warrant Excercise Price
Warrant Excercise Price
Total potentially dilutive shares
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Schedule Of Business Acquisitions By Acquisition [Table]
Schedule Of Business Acquisitions By Acquisition [Table]
Equity Interest Type
Equity Interest Issued Or Issuable By Type [Axis]
Equity Interest Issued or Issuable, Type
Equity Interest Issued Or Issuable Type [Domain]
Chondrial therapeutics inc.
Chondrial Therapeutics Inc. [Member]
Chondrial Therapeutics Inc [Member]
Option Indexed to Issuer's Equity, Type
Option Indexed To Issuers Equity Type [Axis]
Option Indexed to Issuer's Equity, Type
Option Indexed To Issuers Equity Type [Domain]
Business Acquisition [Line Items]
Business Acquisition [Line Items]
Capital stock ownership percentage
Equity Method Investment Ownership Percentage
Common stock, shares issued
Options to purchase stock
Stock Issued During Period Shares Acquisitions
Number of shares of the combined organization owned by Zafgen stockholders
Stockholders Equity Note Changes In Capital Structure Subsequent Changes To Number Of Common Shares
Multiplied by the fair value per share of Zafgen common stock
Business Acquisition Share Price
Fair value of consideration issued in effect of the Merger
Business Combination Consideration Transferred1
Transaction costs
Business Acquisition Cost Of Acquired Entity Transaction Costs
Purchase price:
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Net
Common stock outstanding
Amount of other assets expected to be realized or consumed both before one year or the normal operating cycle, if longer, and after one year or the normal operating cycle, if longer, acquired at the acquisition date.
Amount of cash restricted as to withdrawal or usage, acquired at the acquisition date.
Amount of lessee's right to use underlying asset under operating lease, acquired at the acquisition date.
Amount of lease liabilities due after one year or the normal operating cycle, if longer, assumed at the acquisition date.
Cash and cash equivalents
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Cash And Equivalents
Marketable debt securities
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Current Assets Marketable Securities
Other current and noncurrent assets
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Other Current And Noncurrent Assets
Property and equipment, net
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Property Plant And Equipment
Restricted cash
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Restricted Cash
Right-of-use asset
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Right Of Use Asset
Current liabilities
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Current Liabilities
Lease liability, net of current portion
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Capital Lease Obligation Noncurrent
Purchase price
Cash equivalents and marketable debt securities
Assets Fair Value Disclosure
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Quoted Prices in Active Markets, (Level 1) [Member]
Fair Value Inputs Level1 [Member]
Significant Other Observable Inputs (Level 2) [Member]
Fair Value Inputs Level2 [Member]
Significant Unobservable Inputs (Level 3) [Member]
Fair Value Inputs Level3 [Member]
Investment Type
Investment Type [Axis]
Investments
Investment Type Categorization [Member]
Money Market Funds [Member]
Money Market Funds [Member]
Commercial Paper [Member]
Commercial Paper [Member]
Corporate Bonds [Member]
Corporate Bond Securities [Member]
US Government Securities [Member]
U S Government Corporations And Agencies Securities [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash equivalents
Cash And Cash Equivalents Fair Value Disclosure
Total cash equivalents and marketable debt securities
Marketable debt securities
Marketable Securities
Debt Securities Available For Sale [Table]
Debt Securities Available For Sale [Table]
U.S Government securities (due within 1 year) [Member]
Corporate Bonds (Due within 1 Year) [Member]
Schedule Of Available For Sale Securities [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Gross Unrealized Gains
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
Gross Unrealized Losses
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
Fair Value
Allowance for credit losses
Debt Securities Available For Sale Allowance For Credit Loss
Amount of asset related to consideration paid in advance for costs related to research and development.
Carrying amount as of the balance sheet date of payroll taxes previously overpaid to tax authorities (such as U.S. Federal, state and local tax authorities) representing refunds of overpayments or recoveries based on agreed-upon resolutions of disputes.
Amount of asset recognized from transaction costs incurred in a merger.
Amount due from the sale of tax credits related to research and development, that is expected to be collected within one year or the normal operating cycle, if longer.
Amount of asset related to consideration paid in advance for costs that provide economic benefits in future periods, and amount of other assets that are expected to be realized or consumed within one year or the normal operating cycle, if longer, not separately disclosed.
Prepaid research and development expenses
Prepaid Research And Development Expenses
Prepaid insurance
Prepaid Insurance
Payroll tax receivable
Payroll Taxes Receivable
Capitalized transaction costs
Transaction Costs Capitalized
Research and development tax credit sale receivable
Research And Development Tax Credit Sale Receivable
Other prepaid expenses and other assets
Other Prepaid Expense And Other Current Assets
Total prepaid expenses and other current assets
Computer Equipment [Member]
Computer Equipment [Member]
Lab Equipment [Member]
Equipment [Member]
Furniture and Fixtures [Member]
Furniture And Fixtures [Member]
Fixed assets, gross
Property Plant And Equipment Gross
Less: Accumulated depreciation
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Fixed assets, net
Carrying value as of the balance sheet date of obligations incurred through that date and payable for expenses related to research and development. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accrued research and development expenses
Accrued Research And Development Expense Current
Accrued payroll and related expenses
Employee Related Liabilities Current
Accrued professional fees
Accrued Professional Fees Current
Accrued other
Other Accrued Liabilities Current
Total accrued expenses
Private Placement [Member]
Private Placement [Member]
Related Party Transaction
Related Party Transaction [Axis]
Related Party Transaction
Related Party Transaction [Domain]
MTS Health Partners.
MTS Health Partners [Member]
M T S Health Partners [Member]
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
Piper Sandler & Co.
Piper Sandler & Co [Member]
Piper Sandler Co [Member]
At-the-market equity offering program.
ATM Offering Program [Member]
At The Market Equity Offering Program [Member]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand twenty equity incentive plan.
2020 Equity Incentive Plan [Member]
Two Thousand Twenty Equity Incentive Plan [Member]
Common Stock [Member]
Incentive stock options member.
Incentive Stock Options [Member]
Incentive Stock Options [Member]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event [Member]
Two thousand fourteen stock option and incentive plan and two thousand six stock option plan.
2014 Stock Option and Incentive Plan and 2006 Stock Option Plan [Member]
Two Thousand Fourteen Stock Option And Incentive Plan And Two Thousand Six Stock Option Plan [Member]
Two thousand sixteen equity and incentive plan.
2016 Equity and Incentive Plan [Member]
Two Thousand Sixteen Equity And Incentive Plan [Member]
Nature of Expense
Nature Of Expense [Axis]
Interim Period, Costs Not Allocable
Interim Period Costs Not Allocable [Domain]
Vested recognized immediately.
Vested Recognized Immediately [Member]
Vested Recognized Immediately [Member]
Nonvested recognize over remaining term.
Nonvested Recognize Over Remaining Term [Member]
Nonvested Recognize Over Remaining Term [Member]
Two thousand fourteen stock option and incentive plan.
2014 Stock Option and Incentive Plan [Member]
Two Thousand Fourteen Stock Option And Incentive Plan [Member]
Vesting
Vesting [Axis]
Vesting
Vesting [Domain]
First anniversary.
First Anniversary [Member]
First Anniversary [Member]
Title of Individual
Title Of Individual [Axis]
Title of Individual
Title Of Individual With Relationship To Entity [Domain]
Employees.
Employees [Member]
Employees [Member]
Director [Member]
Director [Member]
2020 Equity Incentive Plan [Member]
Unrecognized compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized
Unrecognized compensation expense recognized period
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Preferred stock, par value
Common stock, par value
Dividend paid
Dividends Payable Current And Noncurrent
Common stock voting rights
Common Stock Voting Rights
Per unit amount of prefunded warrant issued.
Costs incurred during the period related to the issuance of stock and warrants.
Issuance of common stock
Stock Issued During Period Shares New Issues
Share price per share
Shares Issued Price Per Share
Issuance of warrants
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
Warrants price per share
Warrants Issued Price Per Share
Gross proceeds
Proceeds From Issuance Of Private Placement
Warrants exercise price
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Transaction cost
Stock And Warrant Issuance Transaction Costs
The potential aggregate gross sales proceeds available under a sales agreement to sell shares of the Company's common stock.
Aggregate sale of shares of our common stock
Aggregate Gross Sales Proceeds Under Sales Agreement
The fee for services as a percentage of gross proceeds resulting from the sale of shares of common stock under a sales agreement.
Description of sales agreement..
Percentage of compensation for services equal to gross proceeds
Percentage Of Compensation For Services Equal To Gross Proceeds
Sales agreement, description
Sales Agreement Description
Sale of Stock, Price Per Share
Sale Of Stock Price Per Share
The minimum threshold number of shares used to determine the maximum number of shares that may be issued under the Plan.
The maximum number of shares that may be added annually to the threshold number of shares issued under the Plan, as a percentage of the shares issued and outstanding on the last day of the immediately preceding fiscal year.
The term of the plan.
Share-based compensation arrangement by share-based payment award, description
Share Based Compensation Arrangement By Share Based Payment Award Terms Of Award
Shares available for grant
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Minimum level of maximum number of shares allowed to be issued
Share Based Compensation Arrangement By Share Based Payment Award Threshold Number Of Shares Allowed To Issue
Increase in shares reserved for future issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized
Maximum number of shares that may be issued under stock option incentive plan
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Percentage of outstanding shares
Share Based Compensation Arrangement By Share Based Payment Award Additional Shares Percentage Of Outstanding Stock
Term of the 2020 plan
Share Based Compensation Arrangement By Share Based Payment Award Duration
Shares reserved for future issuance
Common Stock Capital Shares Reserved For Future Issuance
The increase or decrease in number of shares reserved for issuance under stock option agreements awarded under the plan that validly exist and are outstanding, including vested options.
Issuance of options
Issuance Of Options
The number of outstanding and unexercised options to purchase common units available immediately prior to a merger.
The number of outstanding and unexercised options to purchase common units available immediately after a merger.
The weighted average exercise price of outstanding and unexercised options to purchase common units available immediately after a merger.
The weighted average exercise price of outstanding and unexercised options to purchase common units available immediately prior to a merger.
Number of options to purchase common unit prior to conversion
Number Of Options To Purchase Common Unit Prior To Conversion
Number of options to purchase common unit post conversion
Number Of Options To Purchase Common Unit Post Conversion
Weighted average exercise price post conversion
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Post Conversion
Weighted average exercise price prior to conversion
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Prior To Conversion
The aggregate grant-date fair value of stock options or units.
Increase in fair value
Increase Decrease In Fair Value Of Price Risk Fair Value Hedging Instruments1
Aggregate grant fair value
Share Based Compensation Arrangement By Share Based Payment Award Aggregate Grant Date Fair Value1
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Expected term (in years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Expected volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
The addition or reduction in the number of reserved shares that could potentially be issued under the option plan attributable to a plan modification.
Number of shares, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Number of shares, Assumed as part of the Merger with Zafgen
Share Based Compensation Arrangement By Share Based Payment Award Options Other Increases Decreases In Period
Number of shares, Modification of stock options
Share Based Compensation Arrangement By Share Based Payment Award Options Modification Of Stock Options
Number of shares, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Number of shares, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Number of shares, Outstanding
Number of shares, Exercisable as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Number of shares, Vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
Weighted average price at which grantees could acquire or could have acquired the underlying shares with respect to a modification of shares reserved for issuance.
Weighted average exercise price, balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Weighted average exercise price, Assumed as part of the Merger with Zafgen
Share Based Compensation Arrangements By Share Based Payment Award Options Other Share Increase Decrease In Period Weighted Average Exercise Price
Weighted average exercise price, Modification of stock options
Share Based Compensation Arrangement By Share Based Payment Award Options Modification Of Stock Options Weighted Average Exercise Price
Weighted average exercise price, Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Weighted average exercise price, Forfeited
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Weighted average exercise price, balance
Weighted average exercise price, Exercisable as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Weighted average exercise price, Vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Weighted average remaining contractual term, outstanding
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Weighted average remaining contractual term, Exercisable as of December 31, 2020
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Weighted average remaining contractual term, Vested and expected to vest as of December 31, 2020
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Aggregate intrinsic value, outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Aggregate intrinsic value, outstanding
Aggregate intrinsic value, exercisable as of December 31, 2020
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Aggregate intrinsic value, Vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Options to purchase shares of common stock granted
Vesting period of stock option
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Stock option vesting percentage
Sharebased Compensation Arrangement By Sharebased Payment Award Award Vesting Rights Percentage
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development [Member]
Research And Development Expense [Member]
General and Administrative [Member]
General And Administrative Expense [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense
Allocated Share Based Compensation Expense
Amount of payment due upon reaching milestone.
The minimum annual royalty payment that is required under a contractual arrangement.
Other Commitments [Table]
Other Commitments [Table]
Legal Entity of Counterparty, Type
Accounts Notes Loans And Financing Receivables By Legal Entity Of Counterparty Type [Axis]
Legal Entity Type of Counterparty
Legal Entity Type Of Counterparty [Domain]
Wake Forest University Health Sciences (WFUHS) [Member]
WFUHS [Member]
Wake Forest University Health Sciences [Member]
Indiana University Research and Technology Corporation.
IU [Member]
Indiana University Research And Technology Corporation [Member]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Pennsylvania [Member]
PENNSYLVANIA
Lease Contractual Term
Lease Contractual Term [Axis]
Lease Contractual Term
Lease Contractual Term [Domain]
Office.
Office [Member]
Office [Member]
Massachusetts [Member]
MOROCCO
Real Estate, Type of Property
Mortgage Loans On Real Estate Description Type Of Property [Axis]
Real Estate
Mortgage Loans On Real Estate Name Property Type [Domain]
Massachusetts [Member]
MASSACHUSETTS
Office Sublease
Office Sublease [Member]
Office Sublease [Member]
First sublease year member.
First Sublease Year [Member]
First Sublease Year [Member]
Final sublease year
Final Sublease Year [Member]
Final Sublease Year [Member]
At sixth anniversary if no events of default.
At Sixth Anniversary If No Events Of Default [Member]
At Sixth Anniversary If No Events Of Default [Member]
Office and Lab.
Office and Lab [Member]
Office And Lab [Member]
Other Commitments [Line Items]
Other Commitments [Line Items]
Milestone payments
Milestone Payment Amount
Annual royalty pay obligation
Minimum Annual Royalty Obligation
The amount that may be deducted from consideration due to Licensor 2 as a percentage of consideration paid to Licensor 1, whereby Licensor 1 is the identified party.
License agreement consideration deduction percentage
License Agreement Consideration Deduction Percentage
Amount of payment due for milestones that have been achieved
The amount of expense recognized during the period related to milestones. Such amount may include, but is not limited to, amounts due for attainment of milestones as well as deductions granted as part of a license agreement.
Milestone expenses
Milestone Expenses
Milestone payments due
Milestone Liability
Lease term commencement date.
Operating lease term
Lessee Operating Lease Term Of Contract
Lease extension period
Lessee Operating Lease Renewal Term
Operating lease liability
Operating Lease Liability
Lease term commencement date
Lease Term Commencement Date
Area of office space.
Letter of credit
Line Of Credit
Area of office space
Area Of Office Space
Lease term expiration date
Lease Expiration Date1
Impairment charges
Asset Impairment Charges
Represents the amount of lease security deposit received by the entity, available in letters of credit.
Annual base rent
Operating Leases Future Minimum Payments Due Future Minimum Sublease Rentals
Lease security deposits letters of credit
Lease Security Deposits Available In Letters Of Credit
Weighted average remaining lease term in years
Operating Lease Weighted Average Remaining Lease Term1
Weighted average discount rate
Operating Lease Weighted Average Discount Rate Percent
Lease expenses
Operating Lease Expense
Leases [Abstract]
2021
Lessee Operating Lease Liability Payments Due Next Twelve Months
2022
Lessee Operating Lease Liability Payments Due Year Two
2023
Lessee Operating Lease Liability Payments Due Year Three
2024
Lessee Operating Lease Liability Payments Due Year Four
Thereafter
Lessee Operating Lease Liability Payments Due After Year Four
Total lease payments
Lessee Operating Lease Liability Payments Due
Less: imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Present value of lease liabilities
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Domestic Tax Authority [Member]
Domestic Country [Member]
Foreign Tax Authority [Member]
Foreign Country [Member]
State and Local Jurisdiction [Member]
State And Local Jurisdiction [Member]
Domestic and state local jurisdiction.
Federal and State [Member]
Domestic And State Local Jurisdiction [Member]
Tax Period
Tax Period [Axis]
Tax Period
Tax Period [Domain]
No expiration.
No Expiration [Member]
No Expiration [Member]
Earliest Tax Year [Member]
Earliest Tax Year [Member]
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Income tax benefit
Income Tax Expense Benefit
Domestic
Income Loss From Continuing Operations Before Income Taxes Domestic
Foreign
Income Loss From Continuing Operations Before Income Taxes Foreign
Loss before income taxes
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Federal statutory income tax rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Federal and state research and development tax credit
Effective Income Tax Rate Reconciliation Tax Credits Research
Nondeductible permanent differences
Effective Income Tax Rate Reconciliation Nondeductible Expense
Change in deferred tax asset valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Effective income tax rate
Effective Income Tax Rate Continuing Operations
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible fixed assets and intangible assets.
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating lease liabilities.
Amount of deferred tax liability attributable to operating lease right of use assets.
Deferred tax assets:
Deferred Tax Assets Gross [Abstract]
Capitalized R&D Expenses
Deferred Tax Assets In Process Research And Development
Stock Based Compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Net operating Loss Carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Tax credit carryforwards
Deferred Tax Assets Tax Credit Carryforwards
Other Temporary Differences
Deferred Tax Assets Other
Fixed Assets & Intangibles
Deferred Tax Assets Fixed Assets And Intangible Assets
Operating Lease Liability
Deferred Tax Assets Operating Lease Liabilities
Total deferred tax assets
Deferred Tax Assets Gross
Deferred tax liabilities:
Deferred Tax Liabilities [Abstract]
Operating Right of Use Asset
Deferred Tax Liabilities Operating Lease R Ight Of Use Assets
Total deferred tax liabilities
Deferred Income Tax Liabilities
Less: Valuation allowance
Deferred Tax Assets Valuation Allowance
Net deferred tax assets / (liabilities)
Deferred Tax Assets Liabilities Net
Amount of increase (decrease) in the valuation allowance due to merger.
Valuation allowance as of the beginning of the year
Increases acquired as a result of the Merger with Zafgen
Valuation Allowance Deferred Tax Asset Change In Amount Merger
Increases recorded to income tax provision
Valuation Allowance Deferred Tax Asset Change In Amount
Valuation Allowance at end of Year
The first year in which a net operating loss carryforward begins to expire.
The amount of limitation on operating loss carryforwards as a percentage of taxable income in any one tax period.
The first year in which a tax credit carryforward begins to expire.
Net operating loss carryforwards and tax credit carryforwards, annual utilization limit due to change in ownership.
Description of the limitation that a capitalized research and development deferred tax asset may be subject to.
Net operating loss carryforwards
Operating Loss Carryforwards
Net operating loss carryforwards, beginning of expiration period
Net Operating Loss Carry Forward Expiration Year Begin
Operating loss carryforwards, minimum percentage of taxable income in tax period
Operating Loss Carryforwards Minimum Percentage Of Taxable Income In Tax Period
Operating loss carryforwards, description
Operating Loss Carryforwards Limitations On Use
Tax credit carryforward
Tax Credit Carryforward Amount
Research and development tax credit carry forwards, beginning of expiration period
Tax Credit Carry Forward Expiration Year Start
Net capitalized R&D deferred tax assets
Net capitalized R&D deferred tax assets realization description
Net Capitalized R D Deferred Tax Assets Realization Description
Net operating loss carryforwards, change in ownership, annual utilization limit
Net Operating Loss Carryforwards And Tax Credit Carryforwards Change In Ownership Annual Utilization Limit
Amount, after allocation of deferred tax liability but before allocation of valuation allowances, of deferred tax asset attributable to deductible differences and carryforwards.
Net deferred tax assets before the valuation allowance
Deferred Tax Assets Net Of Liabilities Before Valuation Allowance
Unrecognized tax benefits
Unrecognized Tax Benefits
Open tax year
Open Tax Year
Period of agreement.
Represents extended term of agreement.
Agreement Expiration Date.
The annual amount of compensation to be paid over the term of a consulting agreement.
The number of restricted common units granted.
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others By Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others Type [Domain]
Consulting Agreement.
Consulting Agreement [Member]
Consulting Agreement [Member]
New Consulting Agreement Member
New Consulting Agreement [Member]
New Consulting Agreement [Member]
Holdings member.
Holdings [Member]
Holdings [Member]
Future Services.
Future Services [Member]
Future Services [Member]
Remaining Restricted Common Units.
Remaining Restricted Common Units [Member]
Remaining Restricted Common Units [Member]
Vests over forty eight months.
Vests Over Forty Eight Months [Member]
Vests Over Forty Eight Months [Member]
Series a preferred unit purchase agreement.
Series A Preferred Unit Purchase Agreement [Member]
Series A Preferred Unit Purchase Agreement [Member]
Series b bridge unit purchase agreement.
Series B Bridge Unit Purchase Agreement [Member]
Series B Bridge Unit Purchase Agreement [Member]
Second series b bridge unit purchase agreement.
Second Series B Bridge Unit Purchase Agreement [Member]
Second Series B Bridge Unit Purchase Agreement [Member]
Laboratory equipment.
Laboratory Equipment [Member]
Laboratory Equipment [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Amount to be paid for consulting services
Amount To Be Paid For Consulting Services
Research and development expense
Restricted common units granted
Partners Capital Account Restricted Common Units Granted
Award vesting
Period of agreement
Period Of Agreement
Extented period of agreement
Extended Period Of Agreement
Agreement expiration date
Agreement Expiration Date
Gross proceeds from sale of equity
Proceeds From Issuance Or Sale Of Equity
Purchased of equipment
Payments To Acquire Machinery And Equipment